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It provides a wider process window, allowing the use of conventional production equipment and processes without special low-temperature or oxygen-free conditions

Changes in mental status are thought to be caused by the liver failing to detoxify neurotoxic compounds like ammonia

Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms

Thirdly, these results need to be interpreted with caution due to the potential differences in T1 and T2 relaxation times between different individuals and groups and their effects on neurochemical concentrations

Both are manageable with a single syringe

In situ gel of lamotrigine for augmented brain delivery: development characterization and pharmacokinetic evaluation