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doi:10.1016/S1043-2760(01)00503-3

In a recent randomized trial, one year of combined GLP-1 therapy with exercise training preserved bone mineral density, while GLP-1 therapy alone decreased bone mineral density [162]

Injection site reactions, weight gain, and hypoglycemia dominate the side effect profile

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It may appear as an orthostatic intolerance, i.e., an inability to adapt hemodynamic parameters (cardiac frequency, blood pressure) to a vertical position, revealing a defective baroreflex-cardiovagal function