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MedicalDaily Evidence Check Study type: Post hoc exploratory epigenetic analysis of a Phase 2b, randomized, double-blind, placebo-controlled clinical trial Published in: Nature Communications (June 2026) Participants: 84 adults with HIV-associated lipohypertrophy (45 semaglutide, 39 placebo) What it found: Semaglutide reduced biological aging rates across multiple epigenetic clocks compared with placebo over 32 weeks Key limitation: Post hoc, exploratory analysis
Testing has revealed contamination rates between 12-58%, with 30% of products containing incorrect amino acid sequences and 65% exceeding endotoxin safety thresholds
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