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A 2024 database study found non-diabetic men prescribed semaglutide for weight loss had a higher recorded rate of erectile dysfunction and low testosterone the opposite of what weight loss usually does

Incretins, the current standard of care for obesity, have drawbacks including GI-side effects, rebound after cessation of treatment, and lean mass loss (140, 159, 160)

Based on this, a personalized dosage plan is created to ensure maximum benefit with minimal risk

And the work isnt done yet

Martinez FJ, de Andrade JA, Anstrom KJ, et al

Study limitations include presence of statistical heterogeneity in the meta-analyses for change in HbA 1c and body weight, assessment of risk of bias solely for the primary outcome, and generalisation of findings mainly to individuals who are overweight or obese and already on metformin-based background therapy