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COVID-19 and toll-like receptor 4 (TLR4): SARS-CoV-2 may bind and activate TLR4 to increase ACE2 expression, facilitating entry and causing hyperinflammation

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Co-delivery systems combining GSH-depleting agents with IDO-1 inhibitors or STING agonists further elevate T-cell infiltration

Maris C, DHaene N, Trpant AL, Le Mercier M, Sauvage S, Allard J, et al