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Reaction (b) is also rapid, but the phosphorylated enzyme can be returned to its native state spontaneously only by hydrolysis at very slow rates or by agents such as N- methyl 2-pyridinium aldoxime (2-PAM) at higher rates

10.1007/s00018-006-6271-8 320 WangJ.TokoroT.MatsuiK.HigaS.KitajimaI

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