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-Synuclein has been reported to cause dysfunction of mitochondrial complex I in PD which in turn increases levels of ROS and consequently ROS-induced oxidative stress (Winklhofer and Haass 2010)

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Conversely, it appears that the IMM prevents rapid equilibration of the IMS and matrix glutathione pools

A39 belongs to the SoLute Carrier 25 (SLC25) family, the largest transporter family that is responsible for translocating diverse metabolite ligands across the mitochondrial inner membrane 1-3