Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis
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This may be managed with well-fitted walking shoes that cushion the feet and redistribute pressure
Findings from the only randomized controlled trial involving liraglutide in this population were compromised due to incorrect participant randomization (Allison et al., 2023)
Wang R, van Keeken NM, Siddiqui S, Dijksman LM, Maudsley S, Derval D, van Dam PS, Martin B
Scientific References GLP-1 Receptor Agonists