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The speed at which a Vitamin B12 shot works can vary depending on several factors, including the individuals level of deficiency, overall health, and the presence of any underlying medical conditions

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10.1016/j.biomaterials.2005.06.038

With the rapid weight reduction caused by GLP-1 agonists, 25 to 40 % of the loss is lean mass (muscle tissue)

"In this study, lower vitamin B12 levels were associated with adverse lipid profiles, higher AIP, and elevated blood pressure, highlighting the potential role of vitamin B12 in cardiovascular health," the study found

So I would just say spend more time on that conversation