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Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite

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doi: 10.1155/2015/897639 129 JiaLTuYJiaXDuQZhengXYuanQet al

Those with uncontrolled hypertension or cardiovascular disease should avoid PT-141

Because of how this peptide affects the brains sexual response circuits