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Slow dose escalation mitigates these effects substantially, and discontinuation due to gastrointestinal intolerance ranges from 3% to 16% across agents, being highest for GLP-1/glucagon dual agonists (e.g., survodutide)

To test whether the strong induction of EMT marker genes after cystine withdrawal goes along with dedifferentiation, I investigated the expression of MITF, the master regulator of melanocytes and melanoma cells [89]

Fecal microbiota transplantation alleviated alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice

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The carnitine shuttle pathway is altered in patients with neovascular age-related macular degeneration

She notes that the prescribing information for these drugs does not disclose the risk of severe gastrointestinal events, including gastroparesis