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Clinical trials show that GLP-1 users can lose approximately 10% or more of muscle mass during treatment, with roughly 2539% of total weight lost coming from lean body mass rather than fat, according to a 2024 PMC review of strategies for minimizing muscle loss during incretin-based therapy

J Urol 163(5):14191423 Beckman J, Koppenol W (1996) Nitric oxide, superoxide and peroxynitrite: the good, the bad, and ugly