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Adverse effects included nausea and vomiting, excessive weight loss in patients with T2DM, and hypoglycemic events in combination with conventional hypoglycemic agents

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In human studies, the expression level of the copper transporter SLC31A1 was directly correlated with atherosclerotic plaque vulnerability [42]

Experimental approachesIC50 calculation of phenformin, metformin, and atpenin A5 For IC 50 calculations with the SARS-CoV-2 strains, Calu-3 cells were seeded into a 96-well flat bottom plate with 4 104 cells per well

Liquid chromatography-tandem mass spectrometry was employed to quantify plasma TMAO, choline and their related metabolites, encompassing TMA, l-carnitine, betaine and dimethylglycine (DMG), which are betaine-related metabolites (Reference Wiedeman, Barr and Green14)

and Mohammad, T.F