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Specifically, while the GLP-1 peptide sequence is identical across mammalian species, the human GLP-1 receptor differs from that of the rat GLP-1 receptor at 42 amino acid residues

Figure 3 Additionally, MB demonstrated a moderate citotoxicity profile against hepatocarcinoma cell line HepG2, yielding an EC 50 of 2.68 1.81 M ( Supplementary Material Figure 1 )

If nausea or vomiting persists despite these measures, and after considering dose reduction, the use of antiemetic and/or prokinetic medications may be appropriate [15]

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This work was supported by grants from the European Unions Horizon Europe Research and Innovation Program under grant agreement 101080465 to A.B., P.F., R.J., J.D