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Patients should contact their GP if symptoms significantly worsen, if new red flag features develop, or if their quality of life is substantially impaired despite treatment

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doi: 10.5603/NMR.2011.0006 4 LiscoGAccardoGPupilliCMalandrinoPDe GeronimoVTriggianiV

The body burns more energy at rest, particularly from fat stores

Notably, many of these non-motor symptoms appear years or even decades before the beginning of overt motor indications, indicating the possibility of serving as early prodromal biomarkers and mirroring the systemic, multisystemic aspect of PD pathogenesis [4]

No synergy with topical treatments