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doi:10.4306/pi.2014.11.2.167

Worst-case: Safety signals, inconsistent data across subgroups, or regulatory objections delay approval into 2028 or beyond or lead to restricted use

While these medications have redefined what is possible in weight management by reducing appetite and improving insulin sensitivity, their effectiveness can come with the unintended consequence of losing muscle mass if no structured plan is in place

They want the patients to die early

The key differences: melasma is deeper in the skin layers, more stubborn to treat, more likely to return, and specifically linked to hormonal and sun triggers rather than local skin injury

8E, F), and a substantial reduction of the myocardial diameter at p 0.05 compared to the hyperthyroid group