David Sinclair: Well, its not too late
The activation degree of classical regulatory pathways such as PINK1/Parkin and BNIP3/NIX, as well as the patency of autophagic flux, directly determines the effect direction of mitophagy
Rastogi A, Thakore P, Leung A, Benavides M, Machado M, Morschauser MA, Hsieh AH: Environmental regulation of notochordal gene expression in nucleus pulposus cells
BPC-157, KPV and TB-500 each received favorable 86 votes with one abstention on Day 1
She remains optimistic about the widespread appeal of these treatments
UK guidelines recommend monitoring clinical response and full blood count (typically at around 2 months) to ensure treatment adequacy, rather than routinely rechecking B12 levels after replacement has started