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Dihexa crosses the BBB and is orally bioavailable

Individuals with dementia are at increased risk of adverse effects of drugs that act on the central nervous system (154), and we think the loss of melanin in neurodegenerative disease may be causing these drug hypersensitivities, as certain drugs have a high binding capacity for tissues containing melanin (155)

- GHK-Cu is a copper-binding peptide studied in advanced research models involving cellular signaling, tissue remodeling, collagen-related pathways, oxidative stress, and skin/hair-focused research applications

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Subsequently, they were subsectioned to 10 M slices using a Cryostat, placed on a charged microscopy slide and processed for TUNEL positivity