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[3] Glycine is also a precursor for several critical biomolecules: it contributes to the synthesis of creatine (essential for muscle-energy storage), porphyrins such as heme, and purines, and it conjugates with bile acids to form bile salts

We also address potential challenges to the clinical translation of targeting UA in neurodegenerative diseases

Oxidative damage can impair the transcription of the most important genes and lead to the occurrence of mutations

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Daisuke Yabe, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1084/jem.20110367