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Studies have shown that physiological levels of ROS can activate the Notch signaling pathway, promoting a balance in the differentiation of intestinal stem cells into absorptive and secretory cells [121]

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Four patients accrued new demyelinating lesions on MRI (one on no DMT, two started on a high-efficacy DMT for the first time in the past 6 months, and one on a high-efficacy DMT) and one patient experienced a new MS attack (treated with interferon beta-1a)