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Cytosolic mtDNA serves as a potent activator of the cGAS-STING pathway, leading to type I IFN production

The medications may even be protective in the right populations

On the other hand, acute subcutaneous (SC) injection of GLP-1 increases HR and BP transiently in healthy human subjects, returning to normal ranges 50-60 min after injection [54]

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Pioneered by Sutherland and his colleagues at the University of Minnesota in 1977 for the treatment of CP, TPIAT has seen a gradual expansion in practice, and specific guideline for selecting patients eligible for TPIAT has also been established [94,99,100]

2023;15: eadg3049