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For people who are not deficient, clinical evidence does not support meaningful fat loss from B12 injections
If NNMT inhibition both restores adipocyte energy expenditure (promoting fat reduction) and supports myogenic differentiation (preserving or enhancing muscle), the net body composition effect could be recomposition simultaneous fat loss and lean mass preservation
Instead, humans have to acquire B12 through food sources, taking supplements, or receiving injections from a healthcare provider when they suspect a low Vitamin B12 level
(September 2014)
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Based on Phase 2 clinical trial protocols conducted by Eli Lilly, initiation was typically at 2 mg administered once weekly via subcutaneous injection
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