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Further evidence of exendin-4-induced mitophagy was obtained by CLEM analysis of INS-1 832/3 SNAP/FLAG-hGLP-1R cells, where we could find instances of SNAP/FLAG-hGLP-1R-positive endolysosomes surrounded by mitochondria (Supplementary Fig

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Therefore, overall, the benefit of GLP-1RAs for heart failure has been difficult to confirm (Figure 1)

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