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Early nano-delivery systems such as liposomes and nanosuspensions initially suffered from storage instability (e.g., payload leakage and particle aggregation), but subsequent formulation optimization has greatly improved their robustness and yielded storage-stable products at scale (187, 188)

Some practitioners use nebulized glutathione to deliver the antioxidant directly to the lung tissue

It typically manifests later in life and is characterized by tremors and a shuffling gait

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Tsai M-C, Huang T-L (2015) Thiobarbituric acid reactive substances (TBARS) is a state biomarker of oxidative stress in bipolar patients in a manic phase

doi:10.1080/07315724.2012.10720430