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Zinc is also involved in the production of metallothionein, and a deficiency in zinc can lead to decreased metallothionein production, further exacerbating copper overload
Although the mechanism of action of DMF is not completely understood in MS, DMF is thought to be an immunomodulatory therapy that decreases inflammatory T cells via increasing nuclear factor erythroid 2related factor 2 (Nrf2) and glutathione (GSH), the cell's regulators of anti-oxidant response (Figure 4) (165)
Rats received a regular diet with 49.39% of energy derived from carbohydrates, 31.67% from protein, and 18.94% from fat
