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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes

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It is the operating environment, two years ahead of loss of exclusivity

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So if someone loses weight on Ozempic, their estrogen levels may shift as a result of the weight loss not because Ozempic is acting on estrogen itself

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