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24 Topiramate, a carbonic anhydrase inhibitor, promotes a decrease in urinary citrate excretion, increase in urinary pH, and hypercalciuria, leading to an increased risk of stone formation

The synergy between these three receptor types appears multiplicative rather than simply additive

Additionally, enrollment timing matters

Surrogate endpoint : misura di laboratorio o istologica (come il miglioramento alla biopsia epatica) utilizzata come proxy del beneficio clinico diretto (sopravvivenza, eventi epatici)