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Treatment with the BCL-2/BCL-xL inhibitor senolytic drug ABT263/Navitoclax improves functional hyperemia in aged mice

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In addition, it needs to be established whether the differential toxicity observed in liver slices can be reproduced using isolated hepatocytes, or in other in vitro models

520 Subsequently, the study observed that treatment with liraglutide, both in vitro (cell culture models) and in vivo (mouse models), inhibited the tumor formation and metastatic capabilities of pancreatic cancer cells by activating GLP-1R

This has been correlated to lifestyle factors such as tobacco smoking, excessive alcohol consumption, or both