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Although semaglutide and SGLT2 inhibitors have complementary and non-overlapping mechanisms of action, the present study cannot determine whether background therapy with SGLT2 inhibitors might have influenced the treatment benefits observed, which is an important question for future trials

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Exenatide and lixisenatide are not recommended in severe renal impairment or end-stage renal disease, while liraglutide, semaglutide, and dulaglutide typically require no dose adjustment

Proc Nutr Soc 66(1):3341

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[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Adams JD, Jr., Lauterburg BH, Mitchell JR