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ERAD safeguards pancreatic -cell identity and insulin secretion Pancreatic -cells are uniquely vulnerable to ER stress due to their high insulin biosynthetic demand

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One patient shared, "I had tried various diets and exercise routines without success

Pdx1, in particular, plays a critical role in the development of the pancreas and the function of cells by binding to regulatory elements and promoting the transcription of the insulin gene (Yang et al., 2012)

Schlums, S