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As these drugs roll out into larger populations of people, rare side effects not seen in clinical trials will also emerge

This practice has been discussed in medical literature as a potential strategy to enhance tolerability, particularly for patients with severe gastrointestinal (GI) side effects common with GLP-1 receptor agonists, by allowing slow, incremental adjustments

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They are undertreated because trial populations have historically skewed male

While both tirzepatide and gallbladder removal can affect digestion, understanding how these factors interact helps optimize treatment outcomes