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It refers to gradually increasing the dose of GLP-1 medications to improve effectiveness while minimizing side effects

Carson MP, Frank MI, Keely E

First Five The patent on semaglutide will expire in five major countries next year

Finally, we compare the beneficial effects of GLP-1 receptor agonists and meal-induced gut GLP-1 secretion on overeating-induced obesity and discuss how combining these approaches may complement each others limitations and serve as a promising long-term strategy for preventing and treating obesity

MedlinePlus Drug Information [6] National Institute of Diabetes and Digestive and Kidney Diseases