Las mujeres del grupo de control haban mantenido su peso reemplazando una comida al da con una alimentacin baja en caloras
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Conclusions Pharmacologic treatment with antiepileptic drugs and antidepressants in patients with co-occurring anxiety and depression, as well as an early nonpharmacologic approach based primarily on physical activity, may be a useful indication in contemporary neurology clinical practice
Patients often notice a reduction in appetite within the first few weeks of treatment, which may lead to decreased food intake and gradual weight loss
This synergy also induces neuronal death: microglial ROS (O 2 - ) and cytokines directly damage neuronal mitochondria, while astrocyte-mediated glutamate excitotoxicity (via calcium overload) and reduced neurotrophic factor (e.g., BDNF) secretion jointly promote apoptosis, necroptosis, and ferroptosis [268,269]
Safe, sustainable reduction often occurs over 612 months depending on starting weight and consistency
