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doi: 10.1016/j.anaerobe.2014.08.010 58 GengH.-W.YinF.-Y.ZhangZ.-F.GongX.YangY

Importantly, the pathophysiological consequences of elevated NET components in the follicular microenvironment are supported by parallel evidence: multiple studies link increased oxidative stress and inflammatory mediators in follicular fluid to reduced oocyte competence, lower fertilization rates, and poorer embryo quality in women with PCOS, providing a biologically plausible pathway by which NET-derived DNA, histones, and proteases could impair gamete quality and fertilization success [55]

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Future research will focus on three directions: Further exploring effects in humans and conducting clinical trials to verify safety and efficacy in human anti-aging, supporting translational application

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This stack is primarily investigated for its potential synergistic effects on tissue regeneration, inflammation modulation, angiogenesis, and soft tissue recovery pathways