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ACS acyl-CoA synthetase ALT alanine aminotransferase AMPK adenosine monophosphate-activated protein kinase AST aspartate aminotransferase BMI body mass index CACT carnitine-acylcarnitine translocase CAT catalase CHB chronic hepatitis B CHC chronic hepatitis C COT carnitine octyltransferase CPT I carnitine palmitoyltransferase I CPT II carnitine palmitoyltransferase II CRP C-reactive protein ER endoplasmic reticulum FBG fasting blood glucose FFAs free fatty acids GPx glutathione peroxidase GR glutathione reductase HbA1c glycosylated hemoglobin HC hip circumference HCC hepatocellular carcinoma HDL-C high dense lipoprotein cholesterol HE hepatic encephalopathy HOMA homeostatic model assessment IGF-1 insulin-like growth factor-1 IMM inner mitochondrial membrane IR insulin resistance LCFA long-chain fatty acids LDL-C low density lipoprotein cholesterol NAFLD non-alcoholic fatty liver disease NASH non-alcoholic steatohepatitis NCT-A number connection test-ANf-B, nuclear factor kappa B NOX nicotinamide adenine dinucleotide phosphate oxidase OMM outer mitochondrial membrane PCD primary carnitine deficiency PDHC pyruvate dehydrogenase complex PPAR peroxisome-activated receptor- PT prothrombin time ROS reactive oxygen species SOD superoxide dismutase SOD2 superoxide dismutase 2 TACE transarterial chemoembolization TB total bilirubin TC cholesterol TG triglyceride TNF- tumor necrosis factor- UPR unfolded protein response WC waistline circumference XO xanthine oxidase SMA -smooth muscle actin -GT -glutamyl transpeptidase

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CJC-1295 binds the GHRH receptor on pituitary somatotrophs while Ipamorelin acts on the distinct GHS-R1a (ghrelin) receptor, producing synergistic, pulsatile GH release in animal models

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