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Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)

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A persons out-of-pocket costs will include their Medicare Part D premium, deductible, coinsurance, and copayment

While both medications belong to the same general category of weekly injectable therapies, the shift involves important differences in mechanism, dosing, and tolerability

The table below compares their impact against other major health burdens