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Recommended Dosage in Patients with Mild (eGFR of 60 to 89 mL/min/1.73 m 2) or Moderate (eGFR of 30 to 59 mL/min/1.73 m 2) Renal Impairment The recommended dosage in patients with acquired HO, BBS, or POMC, PCSK1, or LEPR Deficiency and mild or moderate renal impairment is the same as in those with normal kidney function [see Dosage and Administration (2.2, 2.3)]

This gradual increase reduces nausea, allows smoother digestive adaptation, and helps patients maintain consistent treatment without interruption

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However, Haptoglobin (Hp) mRNA level was not altered due to BSO treatment