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In older women undergoing IVF, researchers have demonstrated that oral administration of 1.8 g/day NAC, starting from the beginning of the menstrual cycle preceding controlled ovarian hyperstimulation and continuing until the trigger day, significantly reduces the gonadotropin dose required and increases the number of high-quality blastocysts

R.GerritsenW.GeertsD.Van Het HofB.et al (2013)