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Jakubowska A, le Roux CW, Viljoen A

Are healthy guys who microdose GLP-1s smart early adopters of a blockbuster healthspan enhancement strategy

For most patients, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) require long-term use to maintain their benefits

However, exploratory analysis revealed that an unbalanced use of rescue medications (e.g., ondansetron, prochlorperazine, promethazine) may have confounded the results

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In the phase 2 trial published in the New England Journal of Medicine, participants on the 12mg dose saw liver fat reductions of up to 82.4%