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In contrast, total BA content in Insr P1195L/ +/HFD liver was not different from that in WT/HFD liver, suggesting that BA content might be maintained through various compensatory mechanisms, such as altered BA synthesis, absorption and secretion

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3 Frontiers in Pharmacology (2024)NNMT as a candidate therapeutic target for metabolic syndrome (review)

It has been shown to increase fat oxidation and energy expenditure by activating REV-ERB/ nuclear receptors, which are central to lipid metabolism and biological clock regulation