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These figures highlight both the urgency of addressing obesity and the opportunities that exist to support people on their weight loss journey

Frontiers in Nutrition , 12 , 1566498

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Because retatrutide slows gastric emptying, the absorption and efficacy of other oral medications including antacids and PPIs may potentially be affected

The route of delivery suggests that the peptides will be able to interact with the GLP-1 receptors on the vagal afferents of the intestine, as is the case for native GLP-1 in healthy individuals

The trial results noted minor improvement exhibited in the subjects cholesterol profiles and glucose tolerance levels