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Out-of-pocket maximums are $8,500 and $17,000 respectively

10.1016/j.metabol.2016.03.009 Metabolism 25 FontanellaR.GhoshP.PesapaneA.TaktazF.PuocciA.FranzeseM.et al (2024)

This means even when one desensitization pathway is blocked, backup systems exist

Additionally, reduced food intake means less diet-induced thermogenesis, the temporary increase in metabolic rate that occurs after eating

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It can range from mild to severe and may require medical attention if it persists