Chalouhi N, Points L, Pierce GL, Ballas Z, Jabbour P, Hasan D
The lab bacteria makes vitamin B12 using the same bacteria found naturally in animals but not derived from animals
Although some of the above statements on individual micronutrients are derived from scientific studies, they have been categorised as "not yet sufficiently proven" by official authorities such as the European Food Safety Authority (EFSA), meaning that no positive effect can be confirmed
The rationale for adding it to tirzepatide is that calorie restriction and GI side effects from GLP-1 medications can reduce B12 absorption, potentially leading to deficiency over time
However, the use of conventional anticancer agents has been highly limited due to the random tissue-distribution of cytotoxic anticancer drugs following systemic administration, which can cause non-specific toxicity to the normal tissues
Furthermore, the lobular distribution is dependent on dose with higher doses tending to produce centrilobular plus mid-lobular (Figure 4) and even panlobular hepatocellular hypertrophy
