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With rising life expectancy, both the prevalence and economic burden of these conditions continue to increase

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The compound demonstrates blood-brain barrier (BBB) penetration efficiency approximately 1000-fold higher than comparable peptidesa critical factor in determining how frequently administration is required to maintain central nervous system concentrations adequate for receptor engagement

For example, the Diabetes Prevention Program is known to reduce the risk of progression to diabetes and is covered by major payers, but has not been meaningfully scaled due to regulatory and implementation barriers [105,106]

doi: 10.1016/j.jaut.2019.102332 346 ChoiIKWangZKeQHongMQianYZhaoXet al