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In addition, EX-527 inhibits abnormal expansion of the extracellular mesangial matrix, reduces the occurrence of glomerular sclerosis by reducing EGFR and platelet-derived growth factor receptor (PDGFR) phosphorylation levels, and blocks pro-fibrotic signaling pathways, further downregulating the expressions of fibrosis markers -SMA, collagen-1, TGF-, vimentin, -tubulin, and fibronectin (Kundu et al., 2020)

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Participants achieved average weight loss of approximately 14% over 64 weeks when analysed regardless of treatment adherence

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Early human work identified daily doses in the range of roughly 12 mg as producing measurable tanning, with conservative protocols starting much lower to limit nausea and flushing [1] [2]