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Nat Rev Endocrinol 21 , 686702 (2025)

The trial evaluated retatrutide, an investigational triple-hormone therapy targeting GIP, GLP-1 and glucagon receptors

More serious but rare side effects can include pancreatitis, gallbladder problems, and kidney issues

32 Although the specific properties that confer differences in efficacy are unclear, the different mechanisms of action are a possible driver that can be explored in future research

Novo Nordisk reports similar weight loss results during clinical trials from people who used the oral medication and the injectables

reaching 50+ pounds typically requires adding movement at some point