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The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc
The UPLC flow rate was set to 0.3 ml min 1 at 60 C using a gradient elution from 10 to 65% B over the course of 4.0 min
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This dual action, controlling blood sugar and significantly reducing hunger, is why they have become such a powerful tool for both diabetes management and weight loss
They can be out of the refrigerator for up to 28 days, but if they stay unrefrigerated for longer than this, the medication will have to be discarded even if the expiration date has not yet passed
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