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The mechanism primarily involves delayed gastric emptying, which increases stomach pressure and promotes acid reflux into the esophagus

Glutathione drives this process

Detection of TGR5, CBS, and CSE in STC-1 cells by RT-PCR STC-1 cells were treated with the RNAqueous reagent (Ambion, Austin, TX) for total RNA extraction

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In the second study 36 patients with OSA and T2D were divided into 2 arms: (i) DAPA arm ( n = 18) all patients received DAPA in a daily dose of 5 mg, which was increased to 10 mg 1 week later