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As the ER is a major source of ROS during oxidative protein folding, zincs antioxidant function is critical to protect protein integrity and maintain proteostasis

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In: Rush A, Altshuler K (eds) DepressionBasic Mechanisms, Diagnosis and Treatment Guilford Press: New York 1986

In total, about 87% of women encounter at least one side effect during metformin use, though these symptoms usually ease as the body adapts to the medication

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If you are pregnant, nursing, or taking medications, consult your healthcare provider before use