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We also solved the crystallographic structures of the C408S, C201S/C408S, and C201S CstB mutants to 2.48 , 2.48 and 3.11 resolution, respectively, by molecular replacement with the wild-type enzyme (see Table S1 for crystallographic statistics)

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By delivering Vitamin C via IV, a higher concentration reaches the bloodstream directly, bypassing the digestive system which can limit its absorption when taken orally

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